Journal of biomedical science · 2019
Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning.
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Wong Henry Sung-Ching, Lin Ying-Ju, Lu Hsing-Fang, Liao Wen-Ling, Chen Chien-Hsiun, Wu Jer-Yuarn, Chang Wei-Chiao, Tsai Fuu-Jen
Аннотация
BACKGROUND: Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, with only recombinant human growth hormone (rhGH) being available.
METHODS: Herein, starting from the identification of 122 genetic loci related to FSS, we adopted a genetic-driven drug discovery bioinformatics pipeline based on functional annotation to prioritize crucial biological FSS-related genes. These genes were suggested to be potential targets for therapeutics.
RESULTS: We discovered five druggable subnetworks, which contained seven FSS-related genes and 17 druggable targerts.
CONCLUSIONS: This study provides a valuable drug repositioning accompanied by corresponding targetable gene clusters for FSS therapy.
METHODS: Herein, starting from the identification of 122 genetic loci related to FSS, we adopted a genetic-driven drug discovery bioinformatics pipeline based on functional annotation to prioritize crucial biological FSS-related genes. These genes were suggested to be potential targets for therapeutics.
RESULTS: We discovered five druggable subnetworks, which contained seven FSS-related genes and 17 druggable targerts.
CONCLUSIONS: This study provides a valuable drug repositioning accompanied by corresponding targetable gene clusters for FSS therapy.