The biobehavioral correlates of post-traumatic brain injury depression.

Traumatic brain injury (TBI), typically resulting from vehicle accidents or acts of violence, is a major public health concern. Survivors often face lifelong impairments affecting functional status, cognition, and mood. Depression, the most common mood disorder affecting TBI survivors, most likely is underdiagnosed and presents differently than primary depression or depression after other brain insults. Unfortunately, few studies have been reported that advance theoretical perspectives on post-TBI depression. Currently, there is some evidence that neurochemical and anatomical changes contribute to post-TBI depression. Interpersonal factors, such as sense of belonging and social support, may contribute to the incidence of post-TBI depression. Because of limited theoretical viewpoints, advances have not been made in cost-effective and efficient interventions for this mood disorder, which prolongs rehabilitation and contributes to family suffering.