Mineral and electrolyte metabolism · 1989
Plasma ouabain-like activity in essential hypertensive patients and in subjects with primary aldosteronism.
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Delva P, Degan M, Capra C, Fallo F, Mantero F, Menegazzi M, Lechi C, Steele A, Lechi A
Аннотация
Plasma from 37 essential hypertensive patients, from 11 subjects with primary aldosteronism and from 23 normotensive subjects was tested for ouabain-like activity. Despite a very substantial overlap, hypertensive patients (both essential and secondary) showed significantly higher levels of a ouabain-like plasma factor compared to normotensive controls. No substantial differences could be detected, however, between the two forms of hypertension; in particular, no significant changes were observed in the low-PRA subgroup. Our results are hardly compatible with the hypothesis that this substance may be of crucial importance in the development either of essential hypertension or of primary aldosteronism.