Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2021
Meningitis and brain abscess formation caused by Cronobacter malonaticus sequence type 440 in a full-term neonate.
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Otake Shogo, Okada Yumiko, Forsythe Stephen James, Kasai Masashi
Аннотация
Cronobacter spp. cause serious diseases, such as necrotizing enterocolitis, bacteremia, and meningitis in neonates and infants. Most Cronobacter-associated meningitis is reportedly due to C. sakazakii and the majority of infections caused by C. malonaticus occur in adults and are less severe. We report the case of meningitis and brain abscess caused by C. malonaticus Sequence Type (ST) 440 in a healthy full-term neonate. We should consider the possibility that full-term neonates may develop meningitis due to C. malonaticus and treat appropriately because its mortality rate is very high, and survivors are usually left with severe neurologic impairment. In addition, C. malonaticus ST440 may have virulence factors that cause neonatal meningitis akin to the previous report of meningitic ST307 strain.