Anticancer research · 2017
Association Between Interleukin-10 Receptors and the CD45-Immunophenotype of Central Nervous System Tumors: A Preliminary Study.
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Zadka Lukasz, Kram Pawel, Koscinski Jeremi, Jankowski Roman, Kaczmarek Mariusz, Piatek Katarzyna, Kulus Michal, Gomułkiewicz Agnieszka, Piotrowska Aleksandra, Dziegiel Piotr
Аннотация
BACKGROUND/AIM: One of the current hypotheses assumes that brain tumors exert an immunosuppressive influence on the surrounding cellular environment. Interleukin-10 (IL-10) is one of the immunosuppressive cytokines modifying the biological activity of cancer. The aim of this study was to assess the expression of IL10R in CD45+ cells within primary brain tumors and metastases and establish its association with tumor basic immunophenotype.
PATIENTS AND METHODS: Tissue samples were obtained intraoperatively during surgeries of 32 patients suffering from meningiomas (n=9), gliomas (n=12) and metastatic tumors (n=11). Expression was assessed with flow cytometry and immunohistochemical reactions.
RESULTS: Expression of IL10R subunits within the leukocyte population (CD45+ cells) was significantly higher in primary tumors than in metastases.
CONCLUSION: To the best of our knowledge, this is the first study describing a correlation between the IL10R expression on leukocytes and histological types of brain tumors.
PATIENTS AND METHODS: Tissue samples were obtained intraoperatively during surgeries of 32 patients suffering from meningiomas (n=9), gliomas (n=12) and metastatic tumors (n=11). Expression was assessed with flow cytometry and immunohistochemical reactions.
RESULTS: Expression of IL10R subunits within the leukocyte population (CD45+ cells) was significantly higher in primary tumors than in metastases.
CONCLUSION: To the best of our knowledge, this is the first study describing a correlation between the IL10R expression on leukocytes and histological types of brain tumors.
Предметные рубрики MeSH
AdultAgedBiomarkers, TumorBrain NeoplasmsFemaleFlow CytometryGliomaHumansImmunohistochemistryImmunophenotypingInterleukin-10 Receptor alpha SubunitInterleukin-10 Receptor beta SubunitLeukocyte Common AntigensLymphocytes, Tumor-InfiltratingMaleMeningeal NeoplasmsMeningiomaMiddle AgedNeoplasm MetastasisPhenotype