European journal of medical research · 2025
Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Qian Xian-Zhe, Hu Jin-Yu, Zeng Yan-Mei, Wei Hong, Wang Xiao-Yu, Chen Cheng, Ge Qian-Min, Zou Jie, Zhou Xian-Mei, Ling Qian, He Liang-Qi, Liao Xuan, Shao Yi
Аннотация
OBJECTIVE: To evaluate changes in retinal layer thickness and microvascular density in pancreatitis patients using optical coherence tomography angiography (OCTA).
METHODS: The study involved 16 pancreatitis patients and 16 healthy controls. Each participant underwent a superficial OCTA scan, with images divided into nine subregions to compare macular retinal thickness (RT) and superficial vascular density (SVD) between groups.
RESULTS: Pancreatitis patients exhibited reduced retinal thickness in specific macular areas, including inner, full, and outer layers (p < 0.05). Additionally, decreased superficial vascular density was noted in inner superior (IS), outer superior (OS), inner nasal (IN), and outer nasal (ON) regions (p < 0.05). ROC curve analysis showed high diagnostic accuracy for full-layer inner superior, outer superior, and outer inferior thickness with areas under the curve of 0.9429, 0.9233, and 0.9990, respectively.
CONCLUSIONS: Pancreatitis is associated with macular retinal thinning and decreased superficial vascular density, offering potential for improved diagnostic imaging.
METHODS: The study involved 16 pancreatitis patients and 16 healthy controls. Each participant underwent a superficial OCTA scan, with images divided into nine subregions to compare macular retinal thickness (RT) and superficial vascular density (SVD) between groups.
RESULTS: Pancreatitis patients exhibited reduced retinal thickness in specific macular areas, including inner, full, and outer layers (p < 0.05). Additionally, decreased superficial vascular density was noted in inner superior (IS), outer superior (OS), inner nasal (IN), and outer nasal (ON) regions (p < 0.05). ROC curve analysis showed high diagnostic accuracy for full-layer inner superior, outer superior, and outer inferior thickness with areas under the curve of 0.9429, 0.9233, and 0.9990, respectively.
CONCLUSIONS: Pancreatitis is associated with macular retinal thinning and decreased superficial vascular density, offering potential for improved diagnostic imaging.