m+Medelevator.RU
← Поиск публикаций
Diabetes · 2015

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors.

СтатьяResearch Support, American Recovery and Reinvestment ActПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Fall Tove, Hägg Sara, Ploner Alexander, Mägi Reedik, Fischer Krista, Draisma Harmen H M, Sarin Antti-Pekka, Benyamin Beben, Ladenvall Claes, Åkerlund Mikael, Kals Mart, Esko Tõnu, Nelson Christopher P, Kaakinen Marika, Huikari Ville, Mangino Massimo, Meirhaeghe Aline, Kristiansson Kati, Nuotio Marja-Liisa, Kobl Michael, Grallert Harald, Dehghan Abbas, Kuningas Maris, de Vries Paul S, de Bruijn Renée F A G, Willems Sara M, Heikkilä Kauko, Silventoinen Karri, Pietiläinen Kirsi H, Legry Vanessa, Giedraitis Vilmantas, Goumidi Louisa, Syvänen Ann-Christine, Strauch Konstantin, Koenig Wolfgang, Lichtner Peter, Herder Christian, Palotie Aarno, Menni Cristina, Uitterlinden André G, Kuulasmaa Kari, Havulinna Aki S, Moreno Luis A, Gonzalez-Gross Marcela, Evans Alun, Tregouet David-Alexandre, Yarnell John W G, Virtamo Jarmo, Ferrières Jean, Veronesi Giovanni, Perola Markus, Arveiler Dominique, Brambilla Paolo, Lind Lars, Kaprio Jaakko, Hofman Albert, Stricker Bruno H, van Duijn Cornelia M, Ikram M Arfan, Franco Oscar H, Cottel Dominique, Dallongeville Jean, Hall Alistair S, Jula Antti, Tobin Martin D, Penninx Brenda W, Peters Annette, Gieger Christian, Samani Nilesh J, Montgomery Grant W, Whitfield John B, Martin Nicholas G, Groop Leif, Spector Tim D, Magnusson Patrik K, Amouyel Philippe, Boomsma Dorret I, Nilsson Peter M, Järvelin Marjo-Riitta, Lyssenko Valeriya, Metspalu Andres, Strachan David P, Salomaa Veikko, Ripatti Samuli, Pedersen Nancy L, Prokopenko Inga, McCarthy Mark I, Ingelsson Erik, ENGAGE Consortium

Аннотация

Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 × 10(-107)) and stratified analyses (all P < 3.3 × 10(-30)). We found evidence of a causal effect of adiposity on blood pressure, fasting levels of insulin, C-reactive protein, interleukin-6, HDL cholesterol, and triglycerides in a nonstratified analysis and in the <55-year stratum. Further, we found evidence of a smaller causal effect on total cholesterol (P for difference = 0.015) in the ≥55-year stratum than in the <55-year stratum, a finding that could be explained by biology, survival bias, or differential medication. In conclusion, this study extends previous knowledge of the effects of adiposity by providing sex- and age-specific causal estimates on cardiovascular risk factors.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты