[Disorder of the thrombocytic-vascular component of hemostasis in thyrotoxicosis].

Hemocoagulation and the platelet-vascular hemostasis mechanism were investigated in 79 patients suffering from thyrotoxicosis of different severity by clinical observations and laboratory studies. Along with hemocoagulation defects, there were revealed thrombocytopenia, reduction of the platelet adhesive-aggregation activity and of the vascular wall resistance. The extent of these disturbances depended on the severity of thyrotoxicosis. In the authors opinion, affection of the platelet-vascular hemostasis component, combined with hemocoagulation disturbances played an important role in the development mechanism of increased hemorrhagic tendency of the tissues and hemorrhagic diathesis in thyrotoxicosis. The necessity of complex treatment of patients with thyrotoxicosis with prescription of agents normalizing hemocoagulation and the platelet-vascular hemostasis mechanism is founded.