Pediatric blood & cancer · 2018
Can myocardial remodeling be a useful surrogate predictor of myocardial iron load? A 3D echocardiographic multicentric study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Agha Hala Mounir, AbdelMassih Antoine Fakhry, AbdelRahman Mohamed Youssef, Milanesi Ornella, Castaldi Biagio, Geranio Giulia, Putti Maria Caterina, Kharabish Ahmed, Esmail Reem, El-Kamah Ghada, Hamdy Mona, El-Baz Heba, Behairy Noha, Hanna Carol, El-Tagy Hassan, Mishriky Mary Atef, Mamdouh Mirna, Antonazzo Livio, Ramadan Tasneem
Аннотация
The relationship between myocardial iron load and eccentric myocardial remodeling remains an under-investigated area; it was thought that remodeling is rather linked to fibrosis. This study aims to determine whether or not measures of remodeling can be used as predictors of myocardial iron. For this purpose, 60 patients with thalassemia were studied with 3D echocardiography and myocardial relaxometry (T2*) by Cardiac MRI. 3D derived sphericity index was significantly higher in patients with myocardial iron load. It was correlated with T2* with a 100% sensitivity and specificity (cut-off value of 0.34) to discriminate between patients with and without myocardial iron overload.