Clinical oral implants research · 2025
Long-Term Treatment Outcomes of Peri-Implantitis Reconstructive Therapy: 7-Year Survival and Success of a Randomized Clinical Trial.
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Isler Sila Cagri, Soysal Fatma, Ceyhanli Tugce, Unsal Berrin, Imber Jean-Claude, Roccuzzo Andrea
Аннотация
OBJECTIVES: To report the 7-year outcomes of a randomized clinical trial evaluating a reconstructive surgical procedure of peri-implantitis with a bone substitute in combination with either concentrated growth factor (CGF) or collagen membrane (CM).
MATERIALS AND METHODS: The original population consisted of 57 patients with at least one implant diagnosed with peri-implantitis exhibiting two-, three-, or four-wall intrabony defects ≥ 3 mm which were filled with a xenogenic bone grafting material and covered with either CGF or CM. Clinical and radiographic parameters, treatment success, and disease recurrence frequencies were evaluated over the 7-year follow-up period of supportive periodontal/peri-implant care. Relationships between prognostic indicators/predictors and treatment success and failure were investigated.
RESULTS: Sixteen patients (24 implants) (CGF group) and 18 (25 implants) (CM group) completed the 7-year follow-up. Although short-term improvements in clinical and radiographic outcomes were observed, a tendency toward relapse was detected through time. At implant level, CM group demonstrated significantly more favorable outcomes for deepest PPD and radiographic vertical defect depth (p = 0.040 and p = 0.043) compared to CGF group. At 7 years, treatment success was achieved in 23.1% of CGF and 30.8% of CM patients, while disease recurrence occurred in 34.6% and 30.8%, respectively (p > 0.05). The presence of baseline suppuration was the only significant patient-level predictor for treatment failure (OR = 15.45; 95% CI: 1.42-168.5; p = 0.02).
CONCLUSION: Both protocols led to comparable clinical and radiographic outcomes. Long-term treatment success was limited, with increasing failure rates over time. Baseline suppuration had a significant negative impact on treatment outcomes.
MATERIALS AND METHODS: The original population consisted of 57 patients with at least one implant diagnosed with peri-implantitis exhibiting two-, three-, or four-wall intrabony defects ≥ 3 mm which were filled with a xenogenic bone grafting material and covered with either CGF or CM. Clinical and radiographic parameters, treatment success, and disease recurrence frequencies were evaluated over the 7-year follow-up period of supportive periodontal/peri-implant care. Relationships between prognostic indicators/predictors and treatment success and failure were investigated.
RESULTS: Sixteen patients (24 implants) (CGF group) and 18 (25 implants) (CM group) completed the 7-year follow-up. Although short-term improvements in clinical and radiographic outcomes were observed, a tendency toward relapse was detected through time. At implant level, CM group demonstrated significantly more favorable outcomes for deepest PPD and radiographic vertical defect depth (p = 0.040 and p = 0.043) compared to CGF group. At 7 years, treatment success was achieved in 23.1% of CGF and 30.8% of CM patients, while disease recurrence occurred in 34.6% and 30.8%, respectively (p > 0.05). The presence of baseline suppuration was the only significant patient-level predictor for treatment failure (OR = 15.45; 95% CI: 1.42-168.5; p = 0.02).
CONCLUSION: Both protocols led to comparable clinical and radiographic outcomes. Long-term treatment success was limited, with increasing failure rates over time. Baseline suppuration had a significant negative impact on treatment outcomes.