Neuroreport · 1998
GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice.
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Date I, Aoi M, Tomita S, Collins F, Ohmoto T
Аннотация
Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor beta superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease.
Предметные рубрики MeSH
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAgingAnimalsAntiparkinson AgentsDopamineGlial Cell Line-Derived Neurotrophic FactorImage Processing, Computer-AssistedImmunohistochemistryMaleMiceMice, Inbred C57BLNeostriatumNerve Growth FactorsNerve Tissue ProteinsNeuroprotective AgentsParkinson Disease, SecondarySubstantia NigraTyrosine 3-Monooxygenase