Journal of neuroimmunology · 2010
Involvement of phosphodiesterases in autoimmune diseases.
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Mizrachi Keren, Aricha Revital, Feferman Tali, Kela-Madar Neta, Mandel Ilana, Paperna Tamar, Miller Ariel, Ben-Nun Avraham, Berrih-Aknin Sonia, Souroujon Miriam C, Fuchs Sara
Аннотация
We have previously shown that several phosphodiesterase (PDE) subtypes are up-regulated in muscles and lymph node cells (LNC) of rats with experimental autoimmune myasthenia gravis (EAMG). In the present study we investigated PDE expression during the course of EAMG and experimental allergic encephalomyelitis (EAE) and found that the up-regulated expression of selected PDE subtypes in both experimental models is correlated with disease severity. In EAMG, PDE expression is correlated also with muscle damage. A similar up-regulation of PDE was also observed in the respective human diseases, MG and multiple sclerosis (MS). Our findings suggest that change in PDE expression levels is a general phenomenon in autoimmune diseases and may also be used as a marker for disease severity.
Предметные рубрики MeSH
AdolescentAdultAnimalsBiomarkersChildDisease Models, AnimalDisease ProgressionEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansIsoenzymesMultiple SclerosisMuscular AtrophyMyasthenia GravisMyasthenia Gravis, Autoimmune, ExperimentalPhosphoric Diester HydrolasesPredictive Value of TestsRatsRats, Inbred LewSeverity of Illness IndexUp-RegulationYoung Adult