The Journal of veterinary medical science · 2024
Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis.
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Ishida Yuya, Yonoichi Sakura, Hara Yukako, Shoda Asuka, Kimura Mako, Murata Midori, Ito Makiko, Nunobiki Sarika, Yoshimoto Ayano, Mantani Youhei, Yokoyama Toshifumi, Hirano Tetsushi, Matsuo Eiko, Ikenaka Yoshinori, Hoshi Nobuhiko
Аннотация
The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target, suggesting CLO may disrupt the immune system. However, the relationship between CLO and atopic dermatitis (AD) is unknown. We administered a no-adverse-effect-level (NOAEL) dose of CLO to male NC/Nga mice with induced AD and measured, at three time points, key AD symptom indicators: epidermal thickening, mast cell number, total plasma IgE, and histamine levels. CLO increased total plasma IgE levels but reduced epidermal thickening, mast cell number, and plasma histamine levels in the early stages of AD. This demonstrates for the first time that CLO exposure inhibits AD's early symptoms.