Journal of clinical periodontology · 2012
Benefits of early systemic antibiotics in localized aggressive periodontitis: a retrospective study.
Сравнительное исследованиеСтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Beliveau Dennis, Magnusson Ingvar, Bidwell John A, Zapert Edward F, Aukhil Ikramuddin, Wallet Shannon M, Shaddox Luciana M
Аннотация
BACKGROUND: Treatment of localized aggressive periodontitis (LAP) may include systemic antibiotics, yet it is unclear at what stage of treatment planning antibiotics are most effective.
AIM: This retrospective analysis compared immediate versus delayed antibiotic therapy on clinical parameters and gingival crevicular fluid (GCF) inflammatory mediators.
MATERIAL AND METHODS: At baseline, 3 months and 6 months after treatment, clinical parameters [probing depth (PD), clinical attachment level (CAL), bleeding on probing (BoP) and plaque] and GCF were collected from LAP participants, who received a 7-day antibiotic regimen immediately (ImA) or 3 months following (DelA) mechanical therapy.
RESULTS: Although both groups presented significant CAL reductions at 6 months, only ImA resulted in a reduction in mean PD at both 3 and 6 months, along with reductions in CAL and BoP at 3 months following therapy. In addition, GCF mediators were higher in DelA group at 3 months post mechanical treatment, but were significantly reduced 6 months following antibiotic therapy.
CONCLUSIONS: ImA and DelA regimens were both effective in improving CAL by 6 months post therapy. However, ImA allowed for better improvement in overall clinical parameters early in the course of treatment, concomitant with lower levels of inflammatory mediators within the GCF.
AIM: This retrospective analysis compared immediate versus delayed antibiotic therapy on clinical parameters and gingival crevicular fluid (GCF) inflammatory mediators.
MATERIAL AND METHODS: At baseline, 3 months and 6 months after treatment, clinical parameters [probing depth (PD), clinical attachment level (CAL), bleeding on probing (BoP) and plaque] and GCF were collected from LAP participants, who received a 7-day antibiotic regimen immediately (ImA) or 3 months following (DelA) mechanical therapy.
RESULTS: Although both groups presented significant CAL reductions at 6 months, only ImA resulted in a reduction in mean PD at both 3 and 6 months, along with reductions in CAL and BoP at 3 months following therapy. In addition, GCF mediators were higher in DelA group at 3 months post mechanical treatment, but were significantly reduced 6 months following antibiotic therapy.
CONCLUSIONS: ImA and DelA regimens were both effective in improving CAL by 6 months post therapy. However, ImA allowed for better improvement in overall clinical parameters early in the course of treatment, concomitant with lower levels of inflammatory mediators within the GCF.
Предметные рубрики MeSH
AdolescentBlack or African AmericanAggressive PeriodontitisAmoxicillinAnti-Infective AgentsChildClinical Trials as TopicCombined Modality TherapyDental ProphylaxisDrug Administration ScheduleDrug Therapy, CombinationFemaleGingival Crevicular FluidHumansLongitudinal StudiesMaleMetronidazolePeriodontal IndexRetrospective StudiesTime FactorsTreatment OutcomeYoung Adult