Signaling pathways in Drosophila testis niche: Local signals that regulate stem cell fate.

Stem cells are located in a well-structured and specialized microenvironment called the niche. The niche provides signaling molecules to control the survival, self-renewal, and differentiation of stem cells. As tissues generally contain different types of stem cells, it is important to understand how these stem cells are coordinately regulated by various signaling pathways. The Drosophila testis niche serves as an excellent model for studying such processes, because it harbors 2 types of stem cells, germline stem cells and somatic cyst stem cells. In this review, we summarize the roles of key signaling pathways in stem cell maintenance and differentiation in the Drosophila testis.