Effect of HD-tDCS combined with working memory training on brain network.

High-Definition transcranial direct current stimulation (HD-tDCS) is a non-invasive electrical stimulation used for modulation of brain function. At present, relevant researches mainly focused on the modulation effects of stimulation, while ignored the neurophysiological mechanism of stimulation process. The main targets of this study were to investigate the effect of stimulation combined with working memory training on brain networks connectivity and information transmission efficiency when the stimulus was applied on left dorsolateral prefrontal cortex (LDLPFC). Partial Directed Coherence (PDC) task-mode brain network analysis results of 34 participants showed that brain networks connectivity in α and β band significantly enhanced, but sham group was less than active group. In addition, active group found that the brain network attribute parameters, such as the clustering coefficient and global efficiency, showed varying degrees of improvement, while there was no significant change in sham group. The above results showed that HD-tDCS acting on working memory training could enhance the brain network connectivity and improve the efficiency of brain clustering and information transmission to a greater extent.