European journal of neurology · 2025
Sex-related differences in amyotrophic lateral sclerosis: A 2-[18F]FDG-PET study.
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Canosa Antonio, Martino Alessio, Manera Umberto, Giuliani Alessandro, Vasta Rosario, Palumbo Francesca, Grassano Maurizio, Morbelli Silvia Daniela, Pardini Matteo, Chiaravalloti Agostino, Schillaci Orazio, Leenders Klaus Leonard, Kogan Rosalie Vered, Polverari Giulia, Zocco Grazia, Pede Francesca Di, Mattei Filippo De, Cabras Sara, Matteoni Enrico, Moglia Cristina, Calvo Andrea, Chiò Adriano, Pagani Marco
Аннотация
PURPOSE: We investigated sex-related brain metabolic differences in Amyotrophic Lateral Sclerosis (ALS) and healthy controls (HC).
METHODS: We collected two equal-sized groups of male (m-ALS) and female ALS (f-ALS) patients (n = 130 each), who underwent 2-[18F]FDG-PET at diagnosis, matched for site of onset, cognitive status and King's stage. We included 168 age-matched healthy controls, half female (f-HC) and half male (m-HC). We compared brain metabolism of males and females separately for ALS and HC, including age as covariate. A differential network analysis was performed to evaluate brain connectivity.
RESULTS: M-ALS showed relative hypometabolism of bilateral medial frontal, parietal and occipital cortices, and left temporal cortex, compared to f-ALS. In node-wise comparison, f-ALS showed significantly higher connectivity in right middle cingulate cortex and left superior and medial frontal gyrus. In HC we did not find any sex-related differences.
CONCLUSION: Sex resulted a major determinant of brain metabolism and connectivity in ALS patients.
METHODS: We collected two equal-sized groups of male (m-ALS) and female ALS (f-ALS) patients (n = 130 each), who underwent 2-[18F]FDG-PET at diagnosis, matched for site of onset, cognitive status and King's stage. We included 168 age-matched healthy controls, half female (f-HC) and half male (m-HC). We compared brain metabolism of males and females separately for ALS and HC, including age as covariate. A differential network analysis was performed to evaluate brain connectivity.
RESULTS: M-ALS showed relative hypometabolism of bilateral medial frontal, parietal and occipital cortices, and left temporal cortex, compared to f-ALS. In node-wise comparison, f-ALS showed significantly higher connectivity in right middle cingulate cortex and left superior and medial frontal gyrus. In HC we did not find any sex-related differences.
CONCLUSION: Sex resulted a major determinant of brain metabolism and connectivity in ALS patients.