Medical physics · 2026
Advancing iris melanoma brachytherapy: Eye plaque models for Monte Carlo simulations and 3D dosimetric datasets.
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Djedouani Marwa, Viner Alex, Fletcher Elizabeth M, Thomson Rowan M
Аннотация
PURPOSE: To develop and benchmark eye plaque models for Monte Carlo (MC) simulation of iris melanoma brachytherapy and to develop a database of 3D dose distributions for the iris plaques containing 103 Pd ${}^{103}{\rm Pd}$ , 125 I ${}^{125}{\rm I}$ , and 131 Cs ${}^{131}{\rm Cs}$ seeds.
ACQUISITION AND VALIDATION METHODS: Five iris plaque models are developed with egs_brachy using published dimensions and material data; previously benchmarked seed models are used. Three plaque models are based on those used by the Mayo Clinic, consisting of a modification of the COMS 22 mm plaque design with a 10 mm void in the center surrounded by an inner collimating lip; plaques span 180 ∘ $180^\circ$ , 270 ∘ $270^\circ$ , and 360 ∘ $360^\circ$ arcs. Two additional plaques are modeled: a modified Iris-270 plaque with no collimating lips; a partially-loaded COMS 22 mm plaque with no insert. Plaques are simulated in a water phantom with dose scored in (0.05 cm ) 3 ${\rm cm})^3$ voxels. Simulations under TG-43 conditions are also carried out. Doses are compared to previously published data for validation.
DATA FORMAT AND USAGE NOTES: The eye plaque models will be distributed with egs_brachy on GitHub (https://github.com/clrp-code/egs_brachy), along with an input file to facilitate custom simulations. The dosimetric database (https://doi.org/10.5281/zenodo.14776641) is comprised of 3D dose distributions for each plaque type, simulation condition, and radionuclides.
POTENTIAL APPLICATIONS: The iris plaque models enable custom simulations with the open-access egs_brachy code. The database of 3D dose distributions supports advanced dose evaluations, as recommended by AAPM Task Group 221 on Ocular Brachytherapy. Overall, this work supports adoption of model-based dose evaluations for brachytherapy as recommended by TG-186.
ACQUISITION AND VALIDATION METHODS: Five iris plaque models are developed with egs_brachy using published dimensions and material data; previously benchmarked seed models are used. Three plaque models are based on those used by the Mayo Clinic, consisting of a modification of the COMS 22 mm plaque design with a 10 mm void in the center surrounded by an inner collimating lip; plaques span 180 ∘ $180^\circ$ , 270 ∘ $270^\circ$ , and 360 ∘ $360^\circ$ arcs. Two additional plaques are modeled: a modified Iris-270 plaque with no collimating lips; a partially-loaded COMS 22 mm plaque with no insert. Plaques are simulated in a water phantom with dose scored in (0.05 cm ) 3 ${\rm cm})^3$ voxels. Simulations under TG-43 conditions are also carried out. Doses are compared to previously published data for validation.
DATA FORMAT AND USAGE NOTES: The eye plaque models will be distributed with egs_brachy on GitHub (https://github.com/clrp-code/egs_brachy), along with an input file to facilitate custom simulations. The dosimetric database (https://doi.org/10.5281/zenodo.14776641) is comprised of 3D dose distributions for each plaque type, simulation condition, and radionuclides.
POTENTIAL APPLICATIONS: The iris plaque models enable custom simulations with the open-access egs_brachy code. The database of 3D dose distributions supports advanced dose evaluations, as recommended by AAPM Task Group 221 on Ocular Brachytherapy. Overall, this work supports adoption of model-based dose evaluations for brachytherapy as recommended by TG-186.