Медицинская библиотека · European journal of cancer (Oxford, England : 1990) · 2024

Alectinib for the treatment of papillary thyroid carcinoma harbouring STRN - ALK fusion.

Buriolla Silvia, Zapelloni Giulia, Cipri Claudia, Pelizzari Giacomo, Follador Alessandro, Cortiula Francesco

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Аннотация

BACKGROUND

Anaplastic Lymphoma Kinase (ALK) rearrangement is a rare alteration in differentiated thyroid carcinomas (DTCs). Due to its low prevalence, a few evidence are available about the use of ALK inhibitors in advanced DTCs.

METHODS

We report the case of a striatin (STRN) - ALK translocated advanced thyroid carcinoma. STRN - ALK translocation was detected by NGS - RNA analysis.

RESULTS

A 74-year-old woman received first line alectinib for the treatment of a STRN - ALK translocated advanced thyroid carcinoma with symptomatic bilateral lung localizations. The dose of alectinib was progressively reduced due to the toxicity, but the treatment is still ongoing after 17 months with complete radiological response and clinical benefit.

CONCLUSION

Here we report the first case in Europe of STRN - ALK translocated advanced thyroid carcinoma successfully treated with alectinib.

Для цитирования: Buriolla Silvia, Zapelloni Giulia, Cipri Claudia, Pelizzari Giacomo, Follador Alessandro, Cortiula Francesco. Alectinib for the treatment of papillary thyroid carcinoma harbouring STRN - ALK fusion.. European journal of cancer (Oxford, England : 1990). 2024. DOI: 10.1016/j.ejca.2024.115193.

Предметные рубрики MeSH

Humans Carbazoles Female Aged Piperidines Anaplastic Lymphoma Kinase Thyroid Neoplasms Thyroid Cancer, Papillary Protein Kinase Inhibitors Oncogene Proteins, Fusion Treatment Outcome Translocation, Genetic Calmodulin-Binding Proteins Membrane Proteins Nerve Tissue Proteins

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