Journal of gastroenterology and hepatology · 2025
Efficacy of Biliary Brush Cytology With Rapid On-Site Cytological Evaluation for the Detection of Malignant Biliary Strictures.
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Shin Il Sang, Myeong Jun Ho, Moon Jong Ho, Lee Yun Nah, Park Jae Woo, Kim Hee Kyung, Yang Jae Kook, Lee Tae Hoon, Cho Young Deok, Park Sang-Heum
Аннотация
BACKGROUND AND AIMS: Brush cytology is a widely used diagnostic method in conjunction with intraductal biopsies during endoscopic retrograde cholangiopancreatography, but its diagnostic yield remains a limitation. This study evaluated the efficacy of biliary cytology using a newly developed brush device with rapid on-site cytological evaluation (ROSE) for detecting malignant biliary strictures (MBSs).
METHODS: In total, 58 patients with suspected intrinsic MBS identified by intraductal ultrasound were enrolled. After achieving tissue sampling with ROSE through a maximum of two brushing passes, a transpapillary forceps biopsy (TPB) was performed. The primary outcome was diagnostic accuracy, and the secondary outcomes were technical success, sampling adequacy, and procedure-related adverse events.
RESULTS: Biliary cytology with ROSE was technically successful in all patients (58/58), with a sampling adequacy of 96.6% (56/58). The technical success and sampling adequacy of TPB were 94.8% (55/58) and 91.4% (53/58), respectively. Brush cytology with ROSE and TPB yielded sensitivity rates of 91.8% and 85.7%, specificity rates of 88.9% for both, and accuracy rates of 88.9% for both. The receiver operating characteristic curve comparing the diagnostic accuracies of brush cytology with ROSE and TPB combined versus TPB alone showed a significantly higher value for the combined approach (0.93) than TPB alone (0.87) (p = 0.010).
CONCLUSION: Biliary brush cytology using a novel brush device with ROSE is effective and can be used complementarily to TPB in patients with suspected MBS.
METHODS: In total, 58 patients with suspected intrinsic MBS identified by intraductal ultrasound were enrolled. After achieving tissue sampling with ROSE through a maximum of two brushing passes, a transpapillary forceps biopsy (TPB) was performed. The primary outcome was diagnostic accuracy, and the secondary outcomes were technical success, sampling adequacy, and procedure-related adverse events.
RESULTS: Biliary cytology with ROSE was technically successful in all patients (58/58), with a sampling adequacy of 96.6% (56/58). The technical success and sampling adequacy of TPB were 94.8% (55/58) and 91.4% (53/58), respectively. Brush cytology with ROSE and TPB yielded sensitivity rates of 91.8% and 85.7%, specificity rates of 88.9% for both, and accuracy rates of 88.9% for both. The receiver operating characteristic curve comparing the diagnostic accuracies of brush cytology with ROSE and TPB combined versus TPB alone showed a significantly higher value for the combined approach (0.93) than TPB alone (0.87) (p = 0.010).
CONCLUSION: Biliary brush cytology using a novel brush device with ROSE is effective and can be used complementarily to TPB in patients with suspected MBS.