Actas dermo-sifiliograficas · 2025
[Translated article] Erythema, Localized Edema and Heat vs Forearm Perimeter Increase. Time to Revise the Consensus Recommendations on the Vortex Provocation Test in Vibratory Urticaria-Angioedema?
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Gatica-Ortega M E, Sánchez-Albisua B, Arranz-Sánchez D M, Pérez-Tato B, Sánchez-Gilo A, Córdoba-Guijarro S, Ortiz-Frutos F J, Hernández-Cano N, Gómez de la Fuente E, Elosua-González M, Bergón-Sendín M, García-Martín C, Sanz-Sánchez T, Mazuela-Díez O, Torres-Aranda R, Vergara-de-la-Campa L, Marinero-Escobedo S, Alegre-Bailo A, Garrido-Ríos A, Tous-Romero F, Busto-Leis J M, Sarró-Fuente C, Rodríguez-Cuadrado F J, García-Piqueras P, Beneyto P, Pastor-Nieto M A
Аннотация
BACKGROUND AND OBJECTIVE: Diagnosis of vibratory urticaria/angioedema is established after performing the vortex provocation test. There is current consensus on measuring the forearm perimeter after running such test to define a positive response to it.
MATERIAL AND METHOD: We evaluated the frequency of prior symptoms following vibratory stimuli in volunteers using a questionnaire, response to the vortex provocation test in the same volunteers (increase in forearm perimeter, erythema, localized edema, heat, and pruritus), inter-rater reliability, and correlation between the scores obtained in the questionnaire and response to the test.
RESULTS: A total of 40 volunteers participated in this survey, 17 of whom were excluded due to dermographism. A total of 59% out of 123 without dermographism responded positively to ≥1 items of the questionnaire. Localized erythema, heat or localized edema were reported in 58.5%, 38.2%, and 32.5%, respectively. A total of 73.6% of volunteers presented with itch. The mean intensity of itch was 3.44, 95% CI, 2.94-3.94. Inter-rater agreement was low regarding the increase in forearm circumference at three levels (intraclass correlation coefficient, 0.477, 95% CI: 0.253-0.634; 0.496, 95% CI: 0.280-0.647; and 0.370, 95% CI: 0.100-0.559, respectively) and optimal regarding erythema, heat and localized edema (kappa index, 0.868; 0.756; and 0.757, respectively). A significant correlation was identified between the questionnaire score and the altered response to the test in its different variables.
CONCLUSIONS: We propose the following variables: erythema; localized edema; heat; and the intensity/speed of onset/duration of pruritus to define a positive response to the vortex provocation test given their ease of execution and optimal inter-observer agreement.
MATERIAL AND METHOD: We evaluated the frequency of prior symptoms following vibratory stimuli in volunteers using a questionnaire, response to the vortex provocation test in the same volunteers (increase in forearm perimeter, erythema, localized edema, heat, and pruritus), inter-rater reliability, and correlation between the scores obtained in the questionnaire and response to the test.
RESULTS: A total of 40 volunteers participated in this survey, 17 of whom were excluded due to dermographism. A total of 59% out of 123 without dermographism responded positively to ≥1 items of the questionnaire. Localized erythema, heat or localized edema were reported in 58.5%, 38.2%, and 32.5%, respectively. A total of 73.6% of volunteers presented with itch. The mean intensity of itch was 3.44, 95% CI, 2.94-3.94. Inter-rater agreement was low regarding the increase in forearm circumference at three levels (intraclass correlation coefficient, 0.477, 95% CI: 0.253-0.634; 0.496, 95% CI: 0.280-0.647; and 0.370, 95% CI: 0.100-0.559, respectively) and optimal regarding erythema, heat and localized edema (kappa index, 0.868; 0.756; and 0.757, respectively). A significant correlation was identified between the questionnaire score and the altered response to the test in its different variables.
CONCLUSIONS: We propose the following variables: erythema; localized edema; heat; and the intensity/speed of onset/duration of pruritus to define a positive response to the vortex provocation test given their ease of execution and optimal inter-observer agreement.