Global trends in norovirus genotype distribution among medically attended children with acute gastroenteritis, 2020-2025.
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Cannon Jennifer L, Bonifacio Joseph, Fumian Tulio M, Pabbaraju Kanti, Pietsch Corinna, Gonzalez Mark D, Hossain Mohammad Enayet, Selvarangan Rangaraj, Buesa Javier, Pan Chao-Yang, Sakon Naomi, Chang Jen-Hung, Hewitt Joanne, Croucher Dawn, White Peter A, Mercer Lewis K, Chuchaona Watchaporn, Martinez Francisco Javier Duarte, Moya Mariel López, Trang Nguyên Vân, Hatyoka Luiza Miyanda, Mans Janet, Niendorf Sandra, Jacobsen Sonja, Mendoza Linda, Alvarez Cindi Dayana, Gomes Karina Alejandra, Degiuseppe Juan Ignacio, Ingunza Alejandra, Varghese Tintu, Lay Margarita K, Santiago Fabian Gómez, Bartlett Eddie, Relja Boris, Barclay Leslie, Simuyandi Michelo, Lanata Claudio F, Rahman Mustafizur, Poovorawan Yong, Wu Fang-Tzy, Pang Xiao-Li, Vinjé Jan
Аннотация
METHODS: Participating laboratories uploaded norovirus sequences from stool specimens collected from 2020 to 2025 to a web portal, which assigned norovirus genotypes and strain data. Norovirus seasons were defined as September 1 to August 31.
RESULTS: Participants in 22 countries across 6 continental regions uploaded 4113 norovirus sequences, including 26 genotypes and 53 strains. GII.4 accounted for 53% (2167/4113), followed by GII.3 (12%), GII.17 (11%), GII.6 (7%), and GII.2 (5%). GII.4 Sydney was the most common variant (47%; 1912/4113), but new GII.4 variants/clusters emerged regionally, with GII.4 San Francisco, GII.4 Wichita and GII.4 Allegany more frequently detected than GII.4 Sydney in 2021-2022 in Africa, 2022-2023 in Central and South America and 2023-2024 in Central America. In 2023-2024, a dramatic rise in GII.17 detection was observed in most regions (32% of all 2024-2025 sequences). In North, Central and South America, Europe and Asia Pacific, GII.17 detection increased as GII.4 detection declined in 2024-2025. Other genotypes (GI.3, GII.1, GII.2, GII.3 and GII.6) had regional peaks, accounting for up to 37% of sequences during a specific season.
CONCLUSIONS: Our data may help guide norovirus vaccine development and provide a baseline of global norovirus strain distribution for evaluating the effectiveness of future vaccines in children. We continue to monitor the shifting distribution of norovirus genotypes through NoroSurv surveillance.