Skull Base Surgery in the Pediatric Population-The 2nd International Collaborative Study (1995-2015).
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Fliss Dan M, Ungar Omer J, Levyn Helena, Valero Cristina, Adilbay Dauren, Eagan Alana, Zheng Junting, Gonen Mithat, Cohen Marc A, Patel Snehal, Ganly Ian, Pai Prathamesh, Castelnuovo Paolo, Gao Fang Ju, Piazza Cesare, Nicolai Piero, Panizza Benedict J, Bowman James, Barnett Catherine, Kowalski Luiz P, Toledo Ronaldo N, DeAlmeida John, Witterick Ian, Herman Philippe, Fontanella Walter, Aniceto Gregorio Sanchez, Hosal Sefik, Ozer Serdar, Iyer Subramania, Harvey Richard, Leemans C Rene, Hendrickx Jan-Jaap, Figari Marcelo, Boccalatte Luis, Nibu Ichi, Clarke Peter, Rennie Catherine, Zhu Yiming, Cernea Claudio, Goncalves Sergio, Schlosser Rodney, Dias Fernando, Sargi Zoukaa, Ahmed Shahzada, Golusinski Wojciech, Kim Se Heon, Su Shirley Y, Raza Shaan M, DeMonte Franco, Hanna Ehab, Shah Jatin P
Аннотация
PATIENTS AND METHODS: A total of 28 institutions contributed data on 3061 patients. From this, there were 64 pediatric patients (2.1%). Clinical variables, overall and disease-free survival (OS and DFS) outcomes, and multivariable factors associated with outcome were evaluated.
RESULTS: The male-to-female ratio was 37:27 and the median [IQR] age at diagnosis was 14.0 [9.6-16.0] years. The most common malignancy was sarcoma (57.8%), followed by esthesioneuroblastoma (25.0%) and carcinoma (17.2%). Negative margins were achieved in 53.1% children. Dural invasion was associated with reduced OS and DFS. Adjuvant radiotherapy was associated with improved survival outcomes.
CONCLUSIONS: Open approaches were widely used for pediatric skull base tumor resection in the period between 1995 and 2015 but we saw a rise in the use of endoscopic and combined techniques by the end of the period covered by this study. Our results may represent a transitional era in which alternative endoscopic techniques continue to expand.