Development and validation of a scoring index to predict the presence of lesions in capsule endoscopy in patients with suspected Crohn's disease of the small bowel: a Spanish multicenter study.
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Egea-Valenzuela Juan, González Suárez Begoña, Sierra Bernal Cristian, Juanmartiñena Fernández José Francisco, Luján-Sanchís Marisol, San Juan Acosta Mileidis, Martínez Andrés Blanca, Pons Beltrán Vicente, Sastre Lozano Violeta, Carretero Ribón Cristina, de Vera Almenar Félix, Sánchez Cuenca Joaquín, Alberca de Las Parras Fernando, Rodríguez de Miguel Cristina, Valle Muñoz Julio, Férnandez-Urién Sainz Ignacio, Torres González Carolina, Borque Barrera Pilar, Pérez-Cuadrado Robles Enrique, Alonso Lázaro Noelia, Martínez García Pilar, Prieto de Frías César, Carballo Álvarez Fernando
Аннотация
OBJECTIVE: Our aim is to develop and validate a scoring index to assess the risk of the patients in this setting on the basis of biomarkers.
PATIENTS AND METHODS: Data on fecal calprotectin, C-reactive protein, and other biomarkers from a population of 124 patients with suspected CD of the small bowel studied by CE and included in a PhD study were used to build a scoring index. This was first used on this population (internal validation process) and after that on a different set of patients from a multicenter study (external validation process).
RESULTS: An index was designed in which every biomarker is assigned a score. Three risk groups have been established (low, intermediate, and high). In the internal validation analysis (124 individuals), patients had a 10, 46.5, and 81% probability of showing inflammatory lesions in CE in the low-risk, intermediate-risk, and high-risk groups, respectively. In the external validation analysis, including 410 patients from 12 Spanish hospitals, this probability was 15.8, 49.7, and 80.6% for the low-risk, intermediate-risk, and high-risk groups, respectively.
CONCLUSION: Results from the internal validation process show that the scoring index is coherent, and results from the external validation process confirm its reliability. This index can be a useful tool for selecting patients before CE studies in cases of suspected CD of the small bowel.