Cancer cell · 2015

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен

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Pajtler Kristian W, Witt Hendrik, Sill Martin, Jones David T W, Hovestadt Volker, Kratochwil Fabian, Wani Khalida, Tatevossian Ruth, Punchihewa Chandanamali, Johann Pascal, Reimand Jüri, Warnatz Hans-Jörg, Ryzhova Marina, Mack Steve, Ramaswamy Vijay, Capper David, Schweizer Leonille, Sieber Laura, Wittmann Andrea, Huang Zhiqin, van Sluis Peter, Volckmann Richard, Koster Jan, Versteeg Rogier, Fults Daniel, Toledano Helen, Avigad Smadar, Hoffman Lindsey M, Donson Andrew M, Foreman Nicholas, Hewer Ekkehard, Zitterbart Karel, Gilbert Mark, Armstrong Terri S, Gupta Nalin, Allen Jeffrey C, Karajannis Matthias A, Zagzag David, Hasselblatt Martin, Kulozik Andreas E, Witt Olaf, Collins V Peter, von Hoff Katja, Rutkowski Stefan, Pietsch Torsten, Bader Gary, Yaspo Marie-Laure, von Deimling Andreas, Lichter Peter, Taylor Michael D, Gilbertson Richard, Ellison David W, Aldape Kenneth, Korshunov Andrey, Kool Marcel, Pfister Stefan M

Аннотация

Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.

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