Медицинская библиотека · Scandinavian journal of gastroenterology · 1996

HLA genotypes and the increased incidence of coeliac disease in Sweden.

Ploski R, Ascher H, Sollid L M

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

BACKGROUND

A strong increase of childhood coeliac disease (CD) was found in Sweden concurrently with changes in the infant feeding pattern. We investigated whether this increase reflects a recruitment of individuals with less predisposing HLA genotypes.

METHODS

Genomic HLA-DRB1, -DQA1, and -DQB1 typing was performed in 135 Swedish patients (48 belonging to a low- and 81 to a high-incidence cohort) and 179 controls. The distribution of HLA class-II genotypes in the cohorts was compared.

RESULTS

DQA1*0501 and DQB1*02 conferred increased risk for CD, and a gene dosage effect of DQB1*02 was found. The distribution of HLA genotypes among the cohorts did not differ.

CONCLUSIONS

The results suggest that Swedish CD patients do not differ in genetic susceptibility compared with other populations. No evidence was found suggesting that the increase would be a result of more frequent development of disease in individuals carrying less predisposing HLA genotypes.

Для цитирования: Ploski R, Ascher H, Sollid L M. HLA genotypes and the increased incidence of coeliac disease in Sweden.. Scandinavian journal of gastroenterology. 1996. DOI: 10.3109/00365529609036892.

Предметные рубрики MeSH

Adolescent Case-Control Studies Celiac Disease Child Child, Preschool Cohort Studies Female Genotype HLA-DQ Antigens HLA-DQ alpha-Chains HLA-DQ beta-Chains HLA-DR Antigens HLA-DRB1 Chains Humans Incidence Infant Infant Food Male Sweden

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