IEEE transactions on bio-medical engineering · 2025
Transcutaneous Spinal Stimulation and Short-Burst Interval Treadmill Training in Children With Cerebral Palsy: A Pilot Study.
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Shrivastav Siddhi R, DeVol Charlotte R, Landrum Victoria M, Bjornson Kristie F, Roge Desiree, Steele Katherine M, Moritz Chet T
Аннотация
OBJECTIVE: The purpose of this pilot study was to evaluate the effects of transcutaneous spinal cord stimulation (tSCS) and short-burst interval locomotor treadmill training (SBLTT) on spasticity and mobility in children with cerebral palsy (CP).
METHODS: We employed a single-arm design with two interventions: SBLTT only, and tSCS + SBLTT, in four children with CP. Children received 24-sessions each of SBLTT only and tSCS + SBLTT. Spasticity, neuromuscular coordination, and walking function were evaluated before, immediately after, and 8-weeks following each intervention.
RESULTS: Spasticity, measured via the Modified Ashworth Scale (MAS), reduced in four lower-extremity muscles after tSCS + SBLTT (1.40 ± 0.22), more than following SBLTT only (0.43 ± 0.39). One-minute walk test (1-MWT) distance was maintained during both interventions. tSCS + SBLTT led to improvements in peak hip and knee extension (4.9 ± 7.3° and 6.5 ± 7.7°), that drove increases in joint dynamic range of 4.3 ± 2.4° and 3.8 ± 8.7° at the hip and knee, respectively. Children and parents reported reduction in fatigue and improved gait outcomes after tSCS + SBLTT. Improvements in spasticity and walking function were sustained for 8-weeks after tSCS + SBLTT.
CONCLUSION: These preliminary results suggest that tSCS + SBLTT may improve spasticity while simultaneously maintaining neuromuscular coordination and walking function in ambulatory children with CP.
SIGNIFICANCE: This work provides preliminary evidence on the effects of tSCS and the combination of tSCS + SBLTT in children with CP.
METHODS: We employed a single-arm design with two interventions: SBLTT only, and tSCS + SBLTT, in four children with CP. Children received 24-sessions each of SBLTT only and tSCS + SBLTT. Spasticity, neuromuscular coordination, and walking function were evaluated before, immediately after, and 8-weeks following each intervention.
RESULTS: Spasticity, measured via the Modified Ashworth Scale (MAS), reduced in four lower-extremity muscles after tSCS + SBLTT (1.40 ± 0.22), more than following SBLTT only (0.43 ± 0.39). One-minute walk test (1-MWT) distance was maintained during both interventions. tSCS + SBLTT led to improvements in peak hip and knee extension (4.9 ± 7.3° and 6.5 ± 7.7°), that drove increases in joint dynamic range of 4.3 ± 2.4° and 3.8 ± 8.7° at the hip and knee, respectively. Children and parents reported reduction in fatigue and improved gait outcomes after tSCS + SBLTT. Improvements in spasticity and walking function were sustained for 8-weeks after tSCS + SBLTT.
CONCLUSION: These preliminary results suggest that tSCS + SBLTT may improve spasticity while simultaneously maintaining neuromuscular coordination and walking function in ambulatory children with CP.
SIGNIFICANCE: This work provides preliminary evidence on the effects of tSCS and the combination of tSCS + SBLTT in children with CP.