Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2015
Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy.
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Enes Coşkun Mehmet, Kervancıoğlu Mehmet, Öztuzcu Serdar, Yılmaz Coşkun Fatma, Ergün Sercan, Başpınar Osman, Kılınç Metin, Temel Levent, Coşkun Mehmet Yavuz
Аннотация
CONTEXT: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes.
OBJECTIVE: We aimed to determine miRNA expression levels in plasma of children with DCM.
MATERIALS AND METHODS: Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children.
RESULTS: The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCM patients.
DISCUSSION: miRNA level differences may provide the chance of using these miRNAs as new biomarkers.
OBJECTIVE: We aimed to determine miRNA expression levels in plasma of children with DCM.
MATERIALS AND METHODS: Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children.
RESULTS: The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCM patients.
DISCUSSION: miRNA level differences may provide the chance of using these miRNAs as new biomarkers.