The use of clomipramine as an REM sleep suppressant in narcolepsy.

Clomipramine is known to suppress REM sleep, and this property may be of value in treating certain features of narcolepsy. In a case reported here, clomipramine produced relief of cataplexy, sleep paralysis and hallucinations with considerable subjective improvement. Although the sleep attacks were little changed, the time spent asleep increased, leaving clearer intervals of wakefulness.