Comparative Evaluation of 68 Ga-FAPI-04 PET/CT and 18 F-FDG-PET/CT in Primary Staging of Treatment-naïve Anterior Mediastinal Seminoma.

A comparative evaluation using both 18 F-FDG-PET/CT and 68 Ga-FAPI-04 PET/CT in primary staging of a treatment-naïve anterior mediastinal seminoma is illustrated in this report. A 30-year-old man presented with elevated human chorionic gonadotropin levels and biopsy-proven seminoma of the anterior mediastinum. The investigation was performed for primary staging, considering that both tracers may show uptake in the germ cell tumors in the anterior mediastinum, and the potential role of 68 Ga-FAPI-04 PET/CT in treatment-naïve mediastinal seminoma would be examined. The germ cell tumors comprise 1%-4% of mediastinal tumors, and seminomas are less frequent than non-seminomatous tumors.