Head & neck · 2017
Improved outcomes with oral tongue squamous cell carcinoma in Finland.
Сравнительное исследованиеСтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Mroueh Rayan, Haapaniemi Aaro, Grénman Reidar, Laranne Jussi, Pukkila Matti, Almangush Alhadi, Salo Tuula, Mäkitie Antti
Аннотация
BACKGROUND: Incidence rates for oral tongue squamous cell carcinoma (SCC) are steadily rising worldwide.
METHODS: All patients diagnosed with primary oral tongue SCC at the 5 university hospitals in Finland from 2005 to 2009 were studied. The mean follow-up time was 43 months (median, 54 months; range, 0-111 months).
RESULTS: Three hundred sixty patients with primary oral tongue SCC were identified. Treatment with curative intent was provided for 328 patients (91%). The 5-year disease-specific survival (DSS) rates were as follows: stage I 87%; stage II 73%; stage III 69%; and stage IV 51%. The 5-year recurrence-free survival in general has improved from 47% in our previous published series (1995-1999) to 65% in the current series (p < .001).
CONCLUSION: The outcome of oral tongue SCC has significantly improved in Finland. However, the relatively high number of disease recurrences in patients with stage I and II disease, when compared with patients with stage III and IV disease, calls for an investigation of new treatment approaches. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1306-1312, 2017.
METHODS: All patients diagnosed with primary oral tongue SCC at the 5 university hospitals in Finland from 2005 to 2009 were studied. The mean follow-up time was 43 months (median, 54 months; range, 0-111 months).
RESULTS: Three hundred sixty patients with primary oral tongue SCC were identified. Treatment with curative intent was provided for 328 patients (91%). The 5-year disease-specific survival (DSS) rates were as follows: stage I 87%; stage II 73%; stage III 69%; and stage IV 51%. The 5-year recurrence-free survival in general has improved from 47% in our previous published series (1995-1999) to 65% in the current series (p < .001).
CONCLUSION: The outcome of oral tongue SCC has significantly improved in Finland. However, the relatively high number of disease recurrences in patients with stage I and II disease, when compared with patients with stage III and IV disease, calls for an investigation of new treatment approaches. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1306-1312, 2017.
Предметные рубрики MeSH
AdultAgedCarcinoma, Squamous CellChemoradiotherapyCohort StudiesCombined Modality TherapyDisease-Free SurvivalFemaleFinlandGlossectomyHospitals, UniversityHumansMaleMiddle AgedMouth NeoplasmsNeoplasm InvasivenessNeoplasm StagingPrognosisQuality ImprovementRadiotherapy, AdjuvantPlastic Surgery ProceduresRetrospective StudiesRisk AssessmentSurvival AnalysisTongue NeoplasmsTreatment Outcome