Fetal and pediatric pathology · 2018
Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes.
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Ataei-Pirkooh Angila, Tehrani Mona, Keyvani Hossein, Esghaei Maryam, Tavakoli Ahmad, Nikmanesh Bahram, Farahmand Mohammad, Ghaffari Hadi, Monavari Seyed Hamidreza
Аннотация
BACKGROUND: Some studies implicate rotavirus infection as a trigger for the development of type 1 diabetes mellitus (T1DM) in children, however findings are controversial.
OBJECTIVES: We investigated the link between rotavirus infection and autoantibodies against islet antigens and T1DM in children.
METHODS: Serum samples from 80 new-onset diabetic and 80 nondiabetic children were screened for anti-rotavirus IgG, anti-GAD65 and anti-IA-2 autoantibodies using ELISA kits.
RESULTS: Positivity percentages of anti-rotavirus IgG detection in diabetic and nondiabetic children were 51.3% and 35.0%, respectively (p = 0.03). The mean anti-GAD65 and anti-IA-2 antibody titers in anti-rotavirus IgG positive samples were statistically higher than that the anti-rotavirus IgG negative samples. A positive correlation was found between anti-rotavirus IgG and anti-GAD65 antibody levels (p = 0.004; r = 0.22).
CONCLUSIONS: Our findings support the hypothesis that rotovirus infection may induce T1DM in children.
OBJECTIVES: We investigated the link between rotavirus infection and autoantibodies against islet antigens and T1DM in children.
METHODS: Serum samples from 80 new-onset diabetic and 80 nondiabetic children were screened for anti-rotavirus IgG, anti-GAD65 and anti-IA-2 autoantibodies using ELISA kits.
RESULTS: Positivity percentages of anti-rotavirus IgG detection in diabetic and nondiabetic children were 51.3% and 35.0%, respectively (p = 0.03). The mean anti-GAD65 and anti-IA-2 antibody titers in anti-rotavirus IgG positive samples were statistically higher than that the anti-rotavirus IgG negative samples. A positive correlation was found between anti-rotavirus IgG and anti-GAD65 antibody levels (p = 0.004; r = 0.22).
CONCLUSIONS: Our findings support the hypothesis that rotovirus infection may induce T1DM in children.