Yao xue xue bao = Acta pharmaceutica Sinica · 2002
[Anti-gastric ulcer sesquiterpene lactone glycosides from Crepis napifera].
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Wu Shao-hua, Luo Xiao-dong, Ma Yun-bao, Hao Xiao-jiang, Wu Da-gang
Аннотация
AIM: The anti-gastric ulcer constituents from the roots of Crepis napifera (Franch) Babc (Compositae) were studied.
METHODS: Solvent partition, Si gel and Rp-18 column chromatography, crystallization and spectral methods were used to extract, isolate and identify two compounds. The activity of compound 1 was tested on the rat stomach by determining the effect on aspirin-induced gastric lesions and on histamine-stimulated gastric acid secretion.
RESULTS: Two sesquiterpene lactone glycosides, taraxinic acid-1'-O-beta-D-glucopyranoside (1) and 11,13-dihydro-taraxinic acid-1'-O-beta-D-glucopyranoside (2) were obtained. Compound 1 at the dose of 80 mg.kg-1 p.o. inhibited significantly the development of aspirin-induced gastric lesions in the rat and at an i.v. dose of 70 mg.kg-1 did not affect histamine-stimulated gastric acid secretion in the lumen-perfused rat stomach.
CONCLUSION: Compound 1 is the active component of the plant which protects gastric mucosa and exhibits anti-gastric ulcer action.
METHODS: Solvent partition, Si gel and Rp-18 column chromatography, crystallization and spectral methods were used to extract, isolate and identify two compounds. The activity of compound 1 was tested on the rat stomach by determining the effect on aspirin-induced gastric lesions and on histamine-stimulated gastric acid secretion.
RESULTS: Two sesquiterpene lactone glycosides, taraxinic acid-1'-O-beta-D-glucopyranoside (1) and 11,13-dihydro-taraxinic acid-1'-O-beta-D-glucopyranoside (2) were obtained. Compound 1 at the dose of 80 mg.kg-1 p.o. inhibited significantly the development of aspirin-induced gastric lesions in the rat and at an i.v. dose of 70 mg.kg-1 did not affect histamine-stimulated gastric acid secretion in the lumen-perfused rat stomach.
CONCLUSION: Compound 1 is the active component of the plant which protects gastric mucosa and exhibits anti-gastric ulcer action.