A Computational Analysis of the Electric Field Components in Transcranial Direct Current Stimulation.

Realistic electric field (E-field) models of the brain have cast doubt on classical targeting approaches used in transcranial direct current stimulation (tDCS). In apparent contradiction with physiological results, modeling studies predict similar or even higher E-field values in regions between the electrodes distant to the presumed targeted areas. As an explanation, not only the magnitude, but the direction of the E-field over specific cortical structures, have been shown to be determinant for the stimulation outcome. This work examines the magnitude and distribution of tangential and normal E-field components over different cortical areas in a representative brain atlas for various electrode montages commonly used in clinical applications. We have confirmed a general trend in the distribution of tangential and normal E-fields on gyri and sulci areas, respectively, partially independent of electrode configuration. The differences found between the various montages are also discussed.