Gastrointestinal endoscopy · 2010
Endoscopic therapy of small-bowel polyps by double-balloon enteroscopy in patients with Peutz-Jeghers syndrome.
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Gao Hong, van Lier Margot G, Poley Jan Werner, Kuipers Ernst J, van Leerdam Monique E, Mensink Peter B
Аннотация
BACKGROUND: Peutz-Jeghers syndrome (PJS) is a hereditary disorder characterized by mucocutaneous pigmentations and hamartomatous polyps mainly in the small bowel. These polyps may cause complications such as intussusception.
OBJECTIVE: To assess therapeutic efficacy and safety of double-balloon enteroscopy (DBE) for detection and treatment of small-bowel polyps in patients with PJS.
DESIGN: Prospective cohort study.
SETTING: Tertiary-care referral center.
PATIENTS: This study involved 13 patients with PJS, defined as a proven STK11 gene mutation or according to international diagnostic criteria.
INTERVENTION: DBE with enteroscopic removal of pedunculated polyps of > or =10 mm.
MAIN OUTCOME MEASUREMENTS: Location, number and size of small-bowel polyps, polypectomy data, and complications and long-term complications associated with development of small-intestine polyps.
RESULTS: Thirteen patients with PJS (8 male, mean age 31 years) underwent 29 DBE procedures. Ten patients (77%) had a history of partial small-bowel resection because of small-bowel polyps. Small-bowel polyps were found in all 13 patients. The majority of polyps (94%) were located in the proximal jejunum. A total of 82 polyps of > or =10 mm were detected, and 79 (96%) were endoscopically removed without complications. After the introduction of DBE, no small-intestine-polyp-related complications occurred during a follow-up period of 356 person-months.
LIMITATIONS: Small number of patients.
CONCLUSION: DBE is clinically useful and safe for diagnosis and therapy of small-bowel polyps in patients with PJS, even in patients with a history of extensive abdominal surgery. DBE may decrease the need for laparotomy in patients with PJS.
OBJECTIVE: To assess therapeutic efficacy and safety of double-balloon enteroscopy (DBE) for detection and treatment of small-bowel polyps in patients with PJS.
DESIGN: Prospective cohort study.
SETTING: Tertiary-care referral center.
PATIENTS: This study involved 13 patients with PJS, defined as a proven STK11 gene mutation or according to international diagnostic criteria.
INTERVENTION: DBE with enteroscopic removal of pedunculated polyps of > or =10 mm.
MAIN OUTCOME MEASUREMENTS: Location, number and size of small-bowel polyps, polypectomy data, and complications and long-term complications associated with development of small-intestine polyps.
RESULTS: Thirteen patients with PJS (8 male, mean age 31 years) underwent 29 DBE procedures. Ten patients (77%) had a history of partial small-bowel resection because of small-bowel polyps. Small-bowel polyps were found in all 13 patients. The majority of polyps (94%) were located in the proximal jejunum. A total of 82 polyps of > or =10 mm were detected, and 79 (96%) were endoscopically removed without complications. After the introduction of DBE, no small-intestine-polyp-related complications occurred during a follow-up period of 356 person-months.
LIMITATIONS: Small number of patients.
CONCLUSION: DBE is clinically useful and safe for diagnosis and therapy of small-bowel polyps in patients with PJS, even in patients with a history of extensive abdominal surgery. DBE may decrease the need for laparotomy in patients with PJS.