Inflammatory and Antioxidant Status in Peri-Implant Health and Diseases: A Biochemical Analysis.

BACKGROUND

Peri-implant disease pathogenesis results in production of pro-inflammatory mediators. These mediators alter the redox balance leading to decrease in antioxidants. The aim of the study was to compare the levels of interleukin-6 (IL-6) and superoxide dismutase (SOD) in peri-implant health and diseases.

MATERIALS AND

METHODS

The present observational study was carried out from March 2023 to September 2023 in the Department of Implantology, Saveetha Dental College and Hospitals, Chennai, India. A total of 60 patients with peri-implant health (n = 20), peri-implant mucositis (n = 20) and peri-implantitis (n = 20) were enrolled. Unstimulated salivary samples were collected and subjected to ELISA for IL-6 and SOD analysis. IL-6 and SOD levels were then compared between the groups using ANOVA.

RESULTS

There was a statistically significant difference in IL-6 and SOD levels between the three groups with p value of 0.003 and 0.000 respectively.

CONCLUSION

The present study suggests that IL-6 level increases and SOD level decreases with severity of peri-implant diseases.