[Frequent occurrence of contrast medium reactions in urograms following accidents in childhood].

Between 30.8.1973 and 30.11.1982 3.200 intravenous urograms were performed with Urografin 76% in patients aged from 0 to 16 years. With regard to the incidence of contrast medium reactions, there was a distinct difference between children who had suffered accidents previously and those who had not: among the former it was 4.24%, in the latter 13.51%. The number of cases appears large enough to rule out randomness. Lalli 's neurodysregulation theory offers the best basis for explaining this highly significant difference: the increased permeability of the blood-brain barrier as a result of microlesions in secondary brain trauma and the increased response of the autonomic nervous system to contrast media which occurs as a result could be a significant factor. However, it does not fully explain the incidents observed. It would be desirable to carry out checks at other clinics and in adults.