Nanomedicine (London, England) · 2025
Polyol-modified deformable liposomes fortified contact lenses for improved ocular permeability.
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Dave Jeel, Jani Harshilkumar, Patel Yashkumar, Mohite Popat, Puri Abhijeet, Chidrawar Vijay R, Datta Deepanjan, Bandi Sony Priyanka, Ranch Ketan, Singh Sudarshan
Аннотация
AIM: To develop a glycerol modified liposomes to effectively deliver active agents into posterior segment of the eye for the management of posterior uveitis.
MATERIALS AND METHODS: The modified liposome enhanced with glycerol as an edge activator was fabricated using a 32 experimental design with independent variables being soya lecithin (mg) (X1) and glycerol (%) (X2) and vesicle size (nm) (Y1), deformability index (%) (Y2), and entrapment efficiency (%) (Y3) as dependent variable with improve permeability and entrapment efficacy. These modified liposomes were then integrated into pHEMA-based contact lenses via free radical polymerization using different monomer mixture, co-polymer, crosslinker, and photo-initiator to extend drug release.
RESULTS AND CONCLUSIONS: Nano-vesicles resulted in size and deformability index of 200.5 ± 15 nm and 11.58, respectively, with entrapment efficiency of 80.98% of the drug. Moreover, the optimized lenses demonstrated 71%) of swelling and transmittance of 87%). In addition, in vitro release of active component from the therapeutic contact lens demonstrated sustained drug release over 24 h. Whereas ex vivo studies displayed a 5-fold increase in drug permeation, compared to tested conventional eye drops. The results suggested that glycerosomes-loaded contact lens can be a promising alternative for regulated delivery of dexamethasone sodium phosphate in the management of posterior uveitis.
MATERIALS AND METHODS: The modified liposome enhanced with glycerol as an edge activator was fabricated using a 32 experimental design with independent variables being soya lecithin (mg) (X1) and glycerol (%) (X2) and vesicle size (nm) (Y1), deformability index (%) (Y2), and entrapment efficiency (%) (Y3) as dependent variable with improve permeability and entrapment efficacy. These modified liposomes were then integrated into pHEMA-based contact lenses via free radical polymerization using different monomer mixture, co-polymer, crosslinker, and photo-initiator to extend drug release.
RESULTS AND CONCLUSIONS: Nano-vesicles resulted in size and deformability index of 200.5 ± 15 nm and 11.58, respectively, with entrapment efficiency of 80.98% of the drug. Moreover, the optimized lenses demonstrated 71%) of swelling and transmittance of 87%). In addition, in vitro release of active component from the therapeutic contact lens demonstrated sustained drug release over 24 h. Whereas ex vivo studies displayed a 5-fold increase in drug permeation, compared to tested conventional eye drops. The results suggested that glycerosomes-loaded contact lens can be a promising alternative for regulated delivery of dexamethasone sodium phosphate in the management of posterior uveitis.