Medicine · 2020
Anlotinib combined with etoposide for platinum-resistant recurrent ovarian cancer: A case report.
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Sun Li, Yang Meng, Zhang Xuan, Li Hua, Wu Lingying, Zhang Yuzi, Cai Shangli
Аннотация
INTRODUCTION: Platinum-resistant ovarian cancer is characterized by its poor prognosis and limited treatment options. Angiogenesis plays a fundamental role in the development of drug-resistance in ovarian cancer. Anlotinib, a novel oral multi-targeted tyrosine kinase inhibitor which targets a board spectrum of angiogenesis-associated growth factor receptors, has shown promising anti-tumor efficacy in clinical trials. Herein, we report a case of ovarian cancer treated with anlotinib plus etoposide after secondary cytoreductive surgery.
PATIENT CONCERNS: A 45-year-old female with primary platinum-resistant ovarian cancer who progressed rapidly after the first cytoreductive surgery, the second cytoreductive surgery, and several lines of treatment. The patient refused to receive intravenous chemotherapy any more.
DIAGNOSIS: Primary platinum-resistant ovarian cancer.
INTERVENTIONS: The oral combination treatment of anlotinib (12 mg, qd) and etoposide (100 mg, qd) were delivered.
OUTCOMES: Finally, the patient was responsive to the orally treatment of anlotinib combined with etoposide. The patient has been alive with no evidence of disease progression for 18 weeks.
CONCLUSION: Our case suggests that oral treatment of anlotinib combined with etoposide which is acceptable and convenient, may be an additional option for the management of platinum-resistant ovarian cancer.
PATIENT CONCERNS: A 45-year-old female with primary platinum-resistant ovarian cancer who progressed rapidly after the first cytoreductive surgery, the second cytoreductive surgery, and several lines of treatment. The patient refused to receive intravenous chemotherapy any more.
DIAGNOSIS: Primary platinum-resistant ovarian cancer.
INTERVENTIONS: The oral combination treatment of anlotinib (12 mg, qd) and etoposide (100 mg, qd) were delivered.
OUTCOMES: Finally, the patient was responsive to the orally treatment of anlotinib combined with etoposide. The patient has been alive with no evidence of disease progression for 18 weeks.
CONCLUSION: Our case suggests that oral treatment of anlotinib combined with etoposide which is acceptable and convenient, may be an additional option for the management of platinum-resistant ovarian cancer.