[Rinsho ketsueki] The Japanese journal of clinical hematology · 2012
[Treatment outcome of non-Hodgkin lymphoma in childhood: KYCCSG NHL-89, 96].
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Fukano Reiji, Suminoe Aiko, Matsuzaki Akinobu, Inada Hiroko, Nagatoshi Yoshihisa, Ishii Eiichi, Nakayama Hideki, Kawakami Kiyoshi, Moritake Hiroshi, Yanai Fumio, Itonaga Nobuyoshi, Suenobu Soichi, Kikuchi Masahiro, Okamura Jun, Kawano Yoshifumi
Аннотация
Two consecutive treatment protocols, NHL-89 and NHL-96, for pediatric diffuse large cell lymphoma (DLC) and lymphoblastic lymphoma (LBL) were conducted between March 1989 and December 2004 by Kyushu-Yamaguchi Children's Cancer Study Group. Forty-two patients (DLC: 15, LBL: 27) and 34 patients (DLC: 8, LBL: 26) were enrolled in NHL-89 and NHL-96, respectively. DLC patients received induction therapy of high-dose methotrexate (MTX) followed by repeated administration of intermediate MTX. LBL patients received a 4-drug induction followed by intensification, consolidation with cranial radiotherapy (15 to 24Gy), and maintenance. The maintenance phase consisted of multiple drug treatment; including prednisolone, vincristine, cyclophosphamide, and 6-mercaptopurine. With a median follow-up of 150 months for NHL-89 and 90.5 months for NHL-96, the estimated event-free survival at 5 years are 76.2±6.6% and 67.7±8.0%, respectively. Both studies improved the prognosis of DLC and LBL over our previous study of NHL-858.