Nutrients · 2019
Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk.
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Uusitalo Ulla, Andren Aronsson Carin, Liu Xiang, Kurppa Kalle, Yang Jimin, Liu Edwin, Skidmore Jennifer, Winkler Christiane, Rewers Marian J, Hagopian William A, She Jin-Xiong, Toppari Jorma, Ziegler Anette-G, Akolkar Beena, Norris Jill M, Virtanen Suvi M, Krischer Jeffrey P, Agardh Daniel, TEDDY Study Group
Аннотация
Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.