Head & neck · 2025
Oncogenic Human Papillomaviruses Drive One-Third of Sinonasal Squamous Cell Carcinoma and Are Not Mutually Exclusive for Gene Mutations.
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Henrion Maxime, Costes-Martineau Valérie, Bravo Ignacio González, Boulle Nathalie, Solassol Jérôme, Vendrell Julie, Garrel Renaud, Trinquet Aude, Lacheretz-Szablewski Vanessa
Аннотация
BACKGROUND: The detection rate of oncogenic human papillomaviruses (HPVs) in sinonasal squamous cell carcinomas (SNSCCs) varies among studies. The mutational landscape of SNSCCs remains poorly investigated.
METHODS: We investigated the prevalence and prognostic significance of HPV infections based on p16 protein expression, HPV-DNA detection, and E6/E7 mRNA expression using immunohistochemistry, polymerase chain reaction, and in situ hybridization, respectively. In addition, we evaluated the genetic mutations in 59 patients using next-generation sequencing.
RESULTS: One-third of the SNSCCs were truly oncogenic HPV-driven tumors associated with a nonkeratinizing morphology (p = 0.01) and did not correlate with the prognosis. The following gene mutations were detected: TP53, PIK3CA, CDKN2A, EGFR, and FGFR3. These mutations occurred alone, in association with, or with oncogenic HPV.
CONCLUSION: One-third of SNSCCs were high-risk HPV driven lesions. However, gene mutations and HR-HPV infections are not mutually exclusive. Further studies are required to analyze the prognostic value of these associations.
METHODS: We investigated the prevalence and prognostic significance of HPV infections based on p16 protein expression, HPV-DNA detection, and E6/E7 mRNA expression using immunohistochemistry, polymerase chain reaction, and in situ hybridization, respectively. In addition, we evaluated the genetic mutations in 59 patients using next-generation sequencing.
RESULTS: One-third of the SNSCCs were truly oncogenic HPV-driven tumors associated with a nonkeratinizing morphology (p = 0.01) and did not correlate with the prognosis. The following gene mutations were detected: TP53, PIK3CA, CDKN2A, EGFR, and FGFR3. These mutations occurred alone, in association with, or with oncogenic HPV.
CONCLUSION: One-third of SNSCCs were high-risk HPV driven lesions. However, gene mutations and HR-HPV infections are not mutually exclusive. Further studies are required to analyze the prognostic value of these associations.
Предметные рубрики MeSH
HumansFemaleMalePapillomavirus InfectionsMutationCarcinoma, Squamous CellParanasal Sinus NeoplasmsMiddle AgedAgedPrognosisPapillomaviridaeAdultReceptor, Fibroblast Growth Factor, Type 3ImmunohistochemistryCyclin-Dependent Kinase Inhibitor p16Class I Phosphatidylinositol 3-KinasesAged, 80 and overErbB ReceptorsIn Situ HybridizationTumor Suppressor Protein p53Human Papillomavirus Viruses