Cervical Pathology Following HPV Vaccination in Greece: A 10-year HeCPA Observational Cohort Study.
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Paraskevaidis Evangelos, Athanasiou Antonios, Paraskevaidi Maria, Bilirakis Evripidis, Galazios Georgios, Kontomanolis Emmanuel, Dinas Konstantinos, Loufopoulos Aristotelis, Nasioutziki Maria, Kalogiannidis Ioannis, Athanasiadis Apostolos, Papanikolaou Alexios, Vatopoulou Anastasia, Grimbizis Gregorios, Tsolakidis Dimitrios, Daponte Alexandros, Valasoulis George, Gritzeli Stella, Michail Georgios, Adonakis Georgios, Paschopoulos Minas, Tsonis Orestis, Anaforidou Maria-Eugenia, Batistatou Anna, Kyrgiou Maria, HeCPA (Hellenic Cervical Pathology Academic) Group
Аннотация
PATIENTS AND METHODS: This is an observational prospective cohort study performed in 7 academic Obstetrics and Gynaecology Departments across Greece between 2009-2019. Cases were women that had completed HPV vaccination before coitarche and were referred for colposcopy due to abnormal cytology. For each vaccinated woman an unvaccinated matched control was selected.
RESULTS: A total of 849 women who had been vaccinated before coitarche and 849 unvaccinated controls were recruited. The combination of cytological, colposcopic and molecular findings necessitated treatment in only a single case among vaccinated (0.1%) and in 8.4% among unvaccinated.
CONCLUSION: HPV vaccination at a proper age can markedly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity.