Cancer investigation · 2025
Long-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study.
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Uysal Mukremin, Saglam Sezer, Beypınar İsmail, Saglam Esra Kaytan, Mammadov Elkhan, Ocak Birol, Aybi Ozge, Arıkan Rukiye, Ergen Sefika Arzu, Gursoy Pınar, Sakin Abdullah, Kaya Vildan, Ozden Ercan, Eren Tulay, Demiray Atike Gokcen, Oyman Abdilkerim, Tatli Ali Murat, Turk Haci Mehmet, Gulmez Ahmet, Demir Atakan, Alan Özkan, Sakalar Teoman, Sen Erdem, Ucar Gokhan, Kilickap Saadettin, Bilici Ahmet, Oksuz Didem Colpan, Karabulut Bulent
Аннотация
The goal of this study was to look at the long-term survival outcomes and clinical characteristics of stage II/III locally advanced rectal cancer (LARC) patients who acquired pathological complete response (pCR) following neoadjuvant chemoradiotherapy (NCRT). The clinicopathological characteristics and treatment details of 277 LARC patients with pCR, relapse-free survival (RFS), overall survival (OS), and locoregional and systemic recurrence rates, were assessed. The 5-year RFS and OS rates were 85.6% and 90.9%. The rates of local and systemic recurrence were 3.6% and 7.9%. Our study confirmed the favorable results in survival in patients with LARC who achieved pCR.