International journal of pediatric otorhinolaryngology · 2026
Risk prediction model for adverse outcomes during and after cochlear implantation in children with inner ear abnormalities.
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Li Kunjun, Zhou Ruhuan, Zheng Wenwen, Zhang Yanbing, Qiu Jianxin
Аннотация
BACKGROUND: To construct a risk prediction model for adverse outcomes during and after cochlear implantation (CI) in children of different ages with inner ear abnormalities.
METHODS: This retrospective study included children with inner ear abnormalities (including large vestibular aqueduct syndrome, incomplete partition, cochlear hypoplasia, and cochlear common cavity malformation) who underwent CI from January 2011 to December 2023 at the First Affiliated Hospital of Anhui Medical University. The patients were divided into two groups based on the occurrence of adverse outcomes during the perioperative and postoperative periods. The patients were divided into age groups (<3, 3-6, and >6 years) to construct three predictive models. Baseline data were collected. Stepwise regression analysis was performed using the entire dataset, and internal validation was carried out using bootstrap resampling.
RESULTS: This study analyzed 609 children with inner ear abnormalities, divided into three age groups: <3, 3-6, and >6 years. Adverse outcomes were associated with various factors, including cochlear ossification, longer surgical time, cochlear hypoplasia, and cochlear common cavity malformation in the <3-year group (AUC = 0.68). In the 3-6-year group, factors included mastoiditis, middle ear malformation, cochlear ossification, and incomplete partition (AUC = 0.75). In the >6-year group, associations were found with middle ear malformation, cochlear ossification, and a high jugular bulb (AUC = 0.69).
CONCLUSIONS: This study developed three nomograms for predicting adverse CI outcomes in patients aged <3, 3-6, and >6 years. These models demonstrate moderate discriminative ability and may serve as exploratory tools to assist in age-specific risk assessment and perioperative counseling for children with inner ear abnormalities.
METHODS: This retrospective study included children with inner ear abnormalities (including large vestibular aqueduct syndrome, incomplete partition, cochlear hypoplasia, and cochlear common cavity malformation) who underwent CI from January 2011 to December 2023 at the First Affiliated Hospital of Anhui Medical University. The patients were divided into two groups based on the occurrence of adverse outcomes during the perioperative and postoperative periods. The patients were divided into age groups (<3, 3-6, and >6 years) to construct three predictive models. Baseline data were collected. Stepwise regression analysis was performed using the entire dataset, and internal validation was carried out using bootstrap resampling.
RESULTS: This study analyzed 609 children with inner ear abnormalities, divided into three age groups: <3, 3-6, and >6 years. Adverse outcomes were associated with various factors, including cochlear ossification, longer surgical time, cochlear hypoplasia, and cochlear common cavity malformation in the <3-year group (AUC = 0.68). In the 3-6-year group, factors included mastoiditis, middle ear malformation, cochlear ossification, and incomplete partition (AUC = 0.75). In the >6-year group, associations were found with middle ear malformation, cochlear ossification, and a high jugular bulb (AUC = 0.69).
CONCLUSIONS: This study developed three nomograms for predicting adverse CI outcomes in patients aged <3, 3-6, and >6 years. These models demonstrate moderate discriminative ability and may serve as exploratory tools to assist in age-specific risk assessment and perioperative counseling for children with inner ear abnormalities.