Tissue distribution of fusion regulatory protein-1 and fusion regulatory protein-2.

OBJECTIVE

To show which organs (tissues or cells) express fusion regulatory protein-1 and -2.

DESIGN

Tissue distribution of fusion regulatory protein-1 and -2 was investigated by indirect immunofluorescence and indirect immunoperoxidase techniques on cryostat tissue sections, using anti-fusion regulatory protein-1 and -2 monoclonal antibodies.

RESULTS

Immunohistochemical analysis of human tissue sections revealed the expression of fusion regulatory protein-1 on hair follicle epithelium, skeletal muscle sarcolemma, some bone marrow stem cells, stomach surface and glandular epithelia, pancreatic islets, kidney proximal tubules, testicular seminiferous tubules, follicular epithelium and ova in the ovary, and parathyroid gland. Fusion regulatory protein-2 was expressed on kidney glomerular basement membrane and many glandular epithelia, such as the skin, stomach, thyroid gland, and lung.

CONCLUSIONS

The distribution suggested that the expression of fusion regulatory protein-1 might be related to proliferation, peptide or protein secretion, and cell fusion. The distribution of fusion regulatory protein-2 was identical to that of the alpha 3 subunit of integrin.