Journal of neuro-oncology · 2025
Integrating a novel tablet-based digital neurocognitive assessment tool in brain metastases patients.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Akdemir Eyub Y, Gurdikyan Selin, Reyes Thailin Companioni, Odia Yazmin, Menendez Miguel A Ramirez, Yarlagadda Sreenija, Gal Omer, Hall Matthew D, Press Robert H, Wieczorek D Jay, Lee Yongsook C, Tolakanahalli Ranjini, Gutierrez Alonso N, McDermott Michael W, Ahluwalia Manmeet S, Mehta Minesh P, Kotecha Rupesh
Аннотация
PURPOSE: Patients with brain metastasis frequently exhibit baseline neurocognitive decline (NCD), which can be further exacerbated by CNS-directed interventions. Despite efforts to measure and preserve neurocognitive function (NCF), the practicality of traditional methods remains a concern. As a contemporary alternative, this study evaluates the feasibility and patient feedback of a novel digital neurocognitive assessment (NCA) tool.
METHODS: Adult patients undergoing stereotactic radiosurgery (SRS), fractionated SRS (FSRS), or whole-brain radiotherapy (WBRT) from December 2021 to March 2024 were enrolled onto a prospective registry (NCT05504681), which formed the basis for this work. The multi-dimensional, multi-language digital NCA battery was administered at baseline and follow-up, and a feedback survey was collected to assess the tool's usability and patient satisfaction.
RESULTS: A "high risk" cohort of 74 patients with brain metastases and a "low risk" cohort of 14 patients with small benign extra-axial tumors were evaluated. The high risk cohort had higher rates of NCD compared to the low risk cohort (36.5% vs. 7.1%, p = 0.032); driven by patients treated with WBRT vs. SRS/FSRS (73.3% vs. 27.1%, p = 0.001). Notably, 50.0% completed the NCAs in their native language (non-English). Patient feedback indicated that 94% found the NCAs easy to understand, 96% found it easy to use, and 74% found it relevant to their care.
CONCLUSION: This multi-dimensional, multi-language tablet-based NCA tool demonstrated feasibility and patient acceptance in a diverse patient population as well as the ability to discriminate NCD among patients treated with SRS/FSRS vs. WBRT. This approach shows promise for broader implementation, warranting further validation to confirm its efficacy.
METHODS: Adult patients undergoing stereotactic radiosurgery (SRS), fractionated SRS (FSRS), or whole-brain radiotherapy (WBRT) from December 2021 to March 2024 were enrolled onto a prospective registry (NCT05504681), which formed the basis for this work. The multi-dimensional, multi-language digital NCA battery was administered at baseline and follow-up, and a feedback survey was collected to assess the tool's usability and patient satisfaction.
RESULTS: A "high risk" cohort of 74 patients with brain metastases and a "low risk" cohort of 14 patients with small benign extra-axial tumors were evaluated. The high risk cohort had higher rates of NCD compared to the low risk cohort (36.5% vs. 7.1%, p = 0.032); driven by patients treated with WBRT vs. SRS/FSRS (73.3% vs. 27.1%, p = 0.001). Notably, 50.0% completed the NCAs in their native language (non-English). Patient feedback indicated that 94% found the NCAs easy to understand, 96% found it easy to use, and 74% found it relevant to their care.
CONCLUSION: This multi-dimensional, multi-language tablet-based NCA tool demonstrated feasibility and patient acceptance in a diverse patient population as well as the ability to discriminate NCD among patients treated with SRS/FSRS vs. WBRT. This approach shows promise for broader implementation, warranting further validation to confirm its efficacy.