European journal of obstetrics, gynecology, and reproductive biology · 2024
Effects of phloroglucinol on uterine peristalsis after frozen embryo transfer in patients experiencing recurrent implantation failure: A retrospective case-control study.
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Ma Wei-Wei, Li Ting-Ting, Li Jing
Аннотация
OBJECTIVE: To retrospectively investigate the efficacy of phloroglucinol administration after freeze-thawed embryo transfer in patients experiencing recurrent implantation failure (RIF).
MATERIALS AND METHODS: A total of 139 infertile couples who experienced RIF undergoing in vitro fertilisation and embryo transfer were divided into the control (n = 66) and the phloroglucinol (n = 73) groups. Women in the phloroglucinol group received 80 mg phloroglucinol 30 min after transfer, then once daily up to day 3 after the embryo transfer. Those in the control group did not receive phloroglucinol.
RESULTS: Administration of phloroglucinol was associated with significantly higher rates of positive pregnancy tests [52.1 % versus (vs) 30.3 %], clinical pregnancy (45.2 % vs 27.3 %), and live births (38.4 % vs 21.2 %) compared with the control group (p < 0.05). Notably, patients with uterine peristalsis exceeding 3 waves/min exhibited significant improvement in positive pregnancy tests (67.6 % vs 38.5 %), implantation (50 % vs 24.6 %), and clinical pregnancy rates (58.8 % vs 33.3 %) following phloroglucinol intervention (p < 0.05).
CONCLUSION: Results suggested that the administration of phloroglucinol after frozen embryo transfer may improve pregnancy outcomes in patients who experienced RIF, primarily in those with uterine peristalsis >3 waves/min.
MATERIALS AND METHODS: A total of 139 infertile couples who experienced RIF undergoing in vitro fertilisation and embryo transfer were divided into the control (n = 66) and the phloroglucinol (n = 73) groups. Women in the phloroglucinol group received 80 mg phloroglucinol 30 min after transfer, then once daily up to day 3 after the embryo transfer. Those in the control group did not receive phloroglucinol.
RESULTS: Administration of phloroglucinol was associated with significantly higher rates of positive pregnancy tests [52.1 % versus (vs) 30.3 %], clinical pregnancy (45.2 % vs 27.3 %), and live births (38.4 % vs 21.2 %) compared with the control group (p < 0.05). Notably, patients with uterine peristalsis exceeding 3 waves/min exhibited significant improvement in positive pregnancy tests (67.6 % vs 38.5 %), implantation (50 % vs 24.6 %), and clinical pregnancy rates (58.8 % vs 33.3 %) following phloroglucinol intervention (p < 0.05).
CONCLUSION: Results suggested that the administration of phloroglucinol after frozen embryo transfer may improve pregnancy outcomes in patients who experienced RIF, primarily in those with uterine peristalsis >3 waves/min.