Proceedings of the National Academy of Sciences of the United States of America · 2022
An inhibitor of leukotriene-A4 hydrolase from bat salivary glands facilitates virus infection.
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Fang Mingqian, Tang Xiaopeng, Zhang Juan, Liao Zhiyi, Wang Gan, Cheng Ruomei, Zhang Zhiye, Zhao Hongwen, Wang Jing, Tan Zhaoxia, Kamau Peter Muiruri, Lu Qiumin, Liu Qi, Deng Guohong, Lai Ren
Аннотация
SignificanceAn immunosuppressant protein (MTX), which facilitates virus infection by inhibiting leukotriene A4 hydrolase (LTA4H) to produce the lipid chemoattractant leukotriene B4 (LTB4), was identified and characterized from the submandibular salivary glands of the bat Myotis pilosus. To the best of our knowledge, this is a report of an endogenous LTA4H inhibitor in animals. MTX was highly concentrated in the bat salivary glands, suggesting a mechanism for the generation of immunological privilege and immune tolerance and providing evidence of viral shedding through oral secretions. Moreover, given that the immunosuppressant MTX selectively inhibited the proinflammatory activity of LTA4H, without affecting its antiinflammatory activity, MTX might be a potential candidate for the development of antiinflammatory drugs by targeting the LTA4-LTA4H-LTB4 inflammatory axis.