Diving and hyperbaric medicine · 2012
The effect of intravenous perfluorocarbon emulsions on whole-body oxygenation after severe decompression sickness.
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Smith Cameron R, Parsons J Travis, Zhu Jiepei, Spiess Bruce D
Аннотация
INTRODUCTION: Decompression sickness (DCS) results from a decrease in ambient pressure leading to supersaturation of tissues with inert gas and bubble formation. Perfluorocarbons (PFCs) are able to dissolve vast amounts of non-polar gases. Intravenous (IV) PFC emulsions reduce both morbidity and mortality associated with DCS, but the mechanism of this protective effect has not yet been demonstrated.
METHODS: Juvenile Dorper-cross sheep (n = 31) were anaesthetised and instrumented for physiological monitoring, IV fluid administration and blood sampling. Animals were compressed in air in a hyperbaric chamber to 608 kPa for 30 minutes and then rapidly decompressed. Upon decompression, animals were randomly assigned to receive 6 mmol per L of PFC or saline over 10 minutes beginning immediately after chamber exit. Arterial and mixed venous bloods were drawn at 5, 10, 15, 30, 60 and 90 minutes to examine pH, partial pressures of oxygen and carbon dioxide, oxygen saturation and electrolytes.
RESULTS: Compared to saline, PFC administration increased arterial oxygen content (16.33 ± 0.28 vs. 14.68 ± 0.26 ml per dL, P < 0.0001), mixed venous oxygen content (12.56 ± 0.28 vs. 11.62 ± 0.26 ml per dL, P = 0.0167), oxygen delivery (14.83 ± 0.28 vs. 13.39 ± 0.26 mmol per L kg, P = 0.0003) and tissue oxygen consumption (3.30 ± 0.15 vs. 2.78 ± 0.13 mmol per L kg, P = 0.0149) but did not increase extraction ratio (0.22 ± 0.012 vs. 0.21 ± 0.011, P = 0.5343).
CONCLUSIONS: It is likely that the improved oxygenation explains, at least in part, the previously-observed therapeutic effects of PFCs in DCS.
METHODS: Juvenile Dorper-cross sheep (n = 31) were anaesthetised and instrumented for physiological monitoring, IV fluid administration and blood sampling. Animals were compressed in air in a hyperbaric chamber to 608 kPa for 30 minutes and then rapidly decompressed. Upon decompression, animals were randomly assigned to receive 6 mmol per L of PFC or saline over 10 minutes beginning immediately after chamber exit. Arterial and mixed venous bloods were drawn at 5, 10, 15, 30, 60 and 90 minutes to examine pH, partial pressures of oxygen and carbon dioxide, oxygen saturation and electrolytes.
RESULTS: Compared to saline, PFC administration increased arterial oxygen content (16.33 ± 0.28 vs. 14.68 ± 0.26 ml per dL, P < 0.0001), mixed venous oxygen content (12.56 ± 0.28 vs. 11.62 ± 0.26 ml per dL, P = 0.0167), oxygen delivery (14.83 ± 0.28 vs. 13.39 ± 0.26 mmol per L kg, P = 0.0003) and tissue oxygen consumption (3.30 ± 0.15 vs. 2.78 ± 0.13 mmol per L kg, P = 0.0149) but did not increase extraction ratio (0.22 ± 0.012 vs. 0.21 ± 0.011, P = 0.5343).
CONCLUSIONS: It is likely that the improved oxygenation explains, at least in part, the previously-observed therapeutic effects of PFCs in DCS.